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Anti-Akt(pan) Monoclonal Antibody
产品名称: Anti-Akt(pan) Monoclonal Antibody
英文名称: Anti-Akt(pan) Monoclonal Antibody
产品编号: K001367M
产品价格: null
产品产地: 北京
品牌商标: solarbio
更新时间: 2025-02-07T13:54:15
使用范围: WB
北京索莱宝科技有限公司
- 联系人 : 索莱宝-龚思雨
- 地址 : 北京市通州区中关村科技园区通州园金桥科技产业基地景盛南四街15号85A三层
- 邮编 : 101102
- 所在区域 : 北京
- 电话 : 178****1073 点击查看
- 传真 : 点击查看
- 邮箱 : 3193328036@qq.com
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Anti-Akt(pan) Monoclonal Antibody
品牌:solarbio | 货号:K001367M
英文名称 | Anti-Akt(pan) Monoclonal Antibody |
---|---|
别名 | Akt(pan) |
应用 | WB |
稀释比例 | WB 1:1000. |
交叉反应 | Mouse Rat |
蛋白分子量 | 60kDa |
Gene ID | 207;208;10000 |
保存 | Store at -20°C. Avoid freeze / thaw cycles. |
储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 | Affinity purification |
亚型 | IgG2b |
免疫原 | Purified recombinant human AKT1 protein fragments expressed in E.coli. |
性状 | 液体 |
Public Immunogen Range | Purified recombinant human AKT1 protein fragments expressed in E.coli. |
Subcellular Locations | Cell membrane Cytoplasm Nucleus |
Swiss Prot | P31749;P31751;Q9Y243 |
克隆号 | 2A4-D4-D11 |
克隆类型 | Monoclonal Antibody |
背景资料 | Akt1 is involved in cellular survival pathways,by inhibiting apoptotic processes.Akt1 is also able to induce protein synthesis pathways,and is therefore a key signaling protein in the cellular pathways that lead to skeletal muscle hypertrophy, and general tissue growth.Since it can block apoptosis,and thereby promote cell survival,Akt1 has been implicated as a major factor in many types of cancer.Akt(now also called Akt1)was originally identified as the oncogene in the transforming retrovirus,AKT8. Akt2 is an important signaling molecule in the Insulin signaling pathway.It is required to induce glucose transport.In a mouse which is null for Akt1 but normal for Akt2,glucose homeostasis is unperturbed,but the animals are smaller,consistent with a role for Akt1 in growth.In contrast,mice which do not have Akt2,but have normal Akt1,have mild growth deficiency and display a diabetic phenotype(insulin resistance),again consistent with the idea that Akt2 is more specific for the insulin receptor signaling pathway. The role of Akt3 is less clear,though it appears to be predominantly expressed in the brain.It has been reported that mice lacking Akt3 have small brains. |